1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester → HCID 53386153, 화합물

HRID 1898515노트

반응식

HRID 1898515 반응식
F[C:2](F)(F)[C:3]([OH:5])=O.[NH2:8][C@H:9]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:10]([N:12]1[CH2:17][CH2:16][CH:15]([C:18]#[N:19])[CH2:14][CH2:13]1)=[O:11].Cl.[NH2:25][C@H:26](C(C)(C)C)[C:27]([N:29]1[CH2:33][CH2:32]CC1)=O.Cl.[N:39]1([C:44]2[CH:45]=[C:46](B(O)O)[CH:47]=[CH:48][CH:49]=2)[CH2:43][CH2:42][CH2:41][CH2:40]1.[CH2:53]([N:55]1C=C(B2OC(C)(C)C(C)(C)O2)C=N1)C>>[C:18]([CH:15]1[CH2:14][CH2:13][N:12]([C:10]([C@H:9]([NH:8][C:3]([C:2]2[C:26]3[C:27](=[N:29][CH:33]=[C:32]([C:46]4[CH:47]=[CH:48][CH:49]=[C:44]([N:39]5[CH2:43][CH2:42][CH2:41][CH2:40]5)[CH:45]=4)[N:25]=3)[NH:55][CH:53]=2)=[O:5])[C:20]([CH3:23])([CH3:22])[CH3:21])=[O:11])[CH2:17][CH2:16]1)#[N:19]

참가 물질

5

반응물 4

HCID 113790451-Ethyl-1H-pyrazole-4-boronic acid, pinacol esterHCID 44754906HCID 44754906, 화합물HCID 57516598(R)-2-amino-3,3-dimethyl-1-(pyrrolidin-1-yl)butan-1-one hydrochlorideHCID 673860481-((R)-2-amino-3,3-dimethyl-butyryl)-piperidine-4-carbonitrile trifluoroacetate

생성물 1

HCID 53386153HCID 53386153, 화합물

실험 절차

Prepared according to the procedure outlined in Example 2 substituting 1-((R)-2-amino-3,3-dimethyl-butyryl)-piperidine-4-carbonitrile trifluoroacetate for (R)-2-amino-3,3-dimethyl-1-pyrrolidin-1-yl-butan-1-one hydrochloride in Step 1 and 3-(1-pyrrolidinyl)phenylboronic acid hydrochloride for 1-ethyl-1H-pyrazole-4-boronic acid pinacol ester in Step 2. MS: (M+H)+=514.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-3f19cc9dc9754a16a7b0290874b26898
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518945B2

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