4-tributylstannanyl-1-(2,3,5-trifluoro-phenyl)-1H-imidazole → 2-[1-(2,3,5-trifluoro-phenyl)-1H-imidazol-4-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide

반응식

C([Sn](CCCC)(CCCC)[C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[C:12]=2[F:19])[CH:10]=1)CCC.[C:28]([CH:30]1[CH2:33][N:32]([C:34](=[O:52])[C@H:35]([NH:39][C:40]([C:42]2[C:50]3[C:45](=[N:46][CH:47]=[C:48](Br)[N:49]=3)[NH:44][CH:43]=2)=[O:41])[CH:36]2[CH2:38][CH2:37]2)[CH2:31]1)#[N:29]>CN(C=O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Cu]I>[C:28]([CH:30]1[CH2:31][N:32]([C:34](=[O:52])[C@H:35]([NH:39][C:40]([C:42]2[C:50]3[C:45](=[N:46][CH:47]=[C:48]([C:6]4[N:7]=[CH:8][N:9]([C:11]5[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[C:12]=5[F:19])[CH:10]=4)[N:49]=3)[NH:44][CH:43]=2)=[O:41])[CH:36]2[CH2:38][CH2:37]2)[CH2:33]1)#[N:29]