Methyl 5-Acetoxy-2-formyl-4-methoxycinnamate → Methyl 5-Acetoxy-2-formyl-4-methoxyhydrocinnamate

HRID 1898761노트

반응식

HRID 1898761 반응식
[C:1]([O:4][C:5]1[C:6]([O:19][CH3:20])=[CH:7][C:8]([CH:17]=[O:18])=[C:9]([CH:16]=1)[CH:10]=[CH:11][C:12]([O:14][CH3:15])=[O:13])(=[O:3])[CH3:2]>[Pd].C(OCC)(=O)C>[C:1]([O:4][C:5]1[C:6]([O:19][CH3:20])=[CH:7][C:8]([CH:17]=[O:18])=[C:9]([CH:16]=1)[CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13])(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 53756943Methyl 5-Acetoxy-2-formyl-4-methoxycinnamate

생성물 1

HCID 23372351Methyl 5-Acetoxy-2-formyl-4-methoxyhydrocinnamate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of methyl 5-acetoxy-2-formyl-4-methoxycinnamate (10.8 g) and 10% palladium on carbon (3 g) in ethyl acetate (100 ml) is hydrogenated at 45 psi for about 18 hours and filtered. The filtrate is concentrated in vacuo and the residue purified by HPLC, eluting 50% ethyl acetate in hexanes, to give the desired product.

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate is concentrated in vacuo
  3. customthe residue purified by HPLC
  4. washeluting 50% ethyl acetate in hexanes

출처 및 근거

ORD 기록
ord-d02b5e2cb1c64e93bd705cc8158c50d1
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05571506

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