Water → 2-(Propan-2-yl)benzene-1-sulfonyl fluoride

HRID 1899010

반응식

HRID 1899010 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10](Cl)(=[O:12])=[O:11])([CH3:3])[CH3:2].[F-:14].[K+].O>O1CCOCC1>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10]([F:14])(=[O:12])=[O:11])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 962Water2회HCID 522689Potassium FluorideHCID 129164822-(Propan-2-yl)benzene-1-sulfonyl chloride

생성물 1

HCID 233731302-(Propan-2-yl)benzene-1-sulfonyl fluoride수율 96.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

27 g of 2-isopropylbenzenesulfonyl chloride and 22 g of KF are stirred in 75 ml of dioxane and 20 ml of water at 45° C. for 27 h and at RT for 45 h. 800 ml of water are then added, and the mixture is extracted with 3×300 ml of EA. The combined organic phases are dried over Na2SO4 and the solvent is removed in vacuo. 24 g of a colorless oil are obtained.

후처리

  1. extractionthe mixture is extracted with 3×300 ml of EA
  2. dry with materialThe combined organic phases are dried over Na2SO4
  3. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-f3291efbbab14b2a9a7fef2bd49b44d7
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05571842

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