Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Iodide → 1-[2-(2-Carboxy-4-chlorophenyl)amino-2-oxoethyl]-4-(2-oxo-1-benzimidazolinyl)piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,3-Dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one | HCID 88638 | — |
| 반응물 | 5-Chloro-2-((2-chloroacetyl)amino)benzoic acid | HCID 4179825 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-[2-(2-Carboxy-4-chlorophenyl)amino-2-oxoethyl]-4-(2-oxo-1-benzimidazolinyl)piperidine | HCID 15221663 | — |
반응 단계
7.94 g (32 mmol) of the compound from Example II and 8.26 g (40 mmol) of 4-(2-oxo-1-benzimidazolinyl)piperidine (Aldrich) are initially introduced in 120 ml of DMF. The mixture is treated with 5.52 g (40 mmol) of potassium carbonate and 0.45 g (3 mmol) of sodium iodide and stirred overnight at room temperature. The batch is diluted with 600 ml of H2O and the product is precipitated at pH 5 by dropwise addition of 33 ml of 1N hydrochloric acid. The precipitate is filtered off with suction, stirred with 300 ml of diethyl ether and dried in a high vacuum.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05571921 |
| 출처 데이터셋 | uspto-grants-1996_11 |
| ORD ID | ord-b10f7b49606e4a6586371f77f5c2fca8 |
| 출처 메모 | uspto-grants-1996_11 |