Hydrazine → HCID 178457149, 화합물

HRID 1899591

반응식

HRID 1899591 반응식
[NH2:1][NH2:2].[CH2:3]([N:6]([CH2:27][CH2:28][CH3:29])[CH:7]1[CH2:16][CH2:15][C:14]2[C:9](=[C:10]([C:17](=O)[CH2:18][C:19](OC(C)(C)C)=[O:20])[CH:11]=[CH:12][CH:13]=2)[CH2:8]1)[CH2:4][CH3:5]>CO>[CH2:3]([N:6]([CH2:27][CH2:28][CH3:29])[CH:7]1[CH2:16][CH2:15][C:14]2[C:9](=[C:10]([C:17]3[CH:18]=[C:19]([OH:20])[NH:2][N:1]=3)[CH:11]=[CH:12][CH:13]=2)[CH2:8]1)[CH2:4][CH3:5]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 233735202-Di-n-propylamino-8-t-butoxycarbonylacetyl-1,2,3,4-tetrahydronaphthalene

생성물 1

HCID 178457149HCID 178457149, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Hydrazine (1 ml, 32 mmole) was added to a solution of 500 mg (1.34 mmole) of 2-di-n-propylamino-8-t-butoxycarbonylacetyl-1,2,3,4-tetrahydronaphthalene in 25 ml methanol and stirred at room temperature for for 24 hours. The product was isolated by concentrating the reaction mixture followed by flash chromatography, eluting with 1:1 CH2Cl2 :MeOH, and finally crystallizing from MeOH/EtOAc, m.p. 214°-216° C.

후처리

  1. customThe product was isolated
  2. concentrationby concentrating the reaction mixture
  3. washeluting with 1:1 CH2Cl2
  4. customMeOH, and finally crystallizing from MeOH/EtOAc, m.p. 214°-216° C.

출처 및 근거

ORD 기록
ord-1058a3b1da8745469be2171a3c19ff3e
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05571942

연결된 노트

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