Fumaric Acid → HCID 67623235, 화합물

HRID 1899835노트

반응식

HRID 1899835 반응식
[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH:16]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33]>C(O)C>[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33].[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH:16]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 444972Fumaric AcidHCID 545585415-Benzyl-3-[3-(morpholin-4-yl)-3-phenylpropyl]-1,3-oxazolidin-2-one

생성물 1

HCID 67623235HCID 67623235, 화합물수율 100.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5-benzyl-3-(3-morpholino-3-phenylpropyl)-1,3-oxazolidin-2-one (0.26 g, 0.68 mmol) prepared in the same manner as is described in Example 9 and fumaric acid (0.08 g, 0.68 mmol) were dissolved in ethanol. From the resulting solution, ethanol was removed by distillation under reduced pressure. Water was added to the residue and then the resulting solution was concentrated. After the concentration was repeated for three times, the residue was dried in vacuum to obtain 0.34 g of the titled compound as a pale scarlet amorphous product (yield: 100%).

후처리

  1. customFrom the resulting solution, ethanol was removed by distillation under reduced pressure
  2. additionWater was added to the residue
  3. concentrationthe resulting solution was concentrated
  4. concentrationAfter the concentration
  5. customthe residue was dried in vacuum

출처 및 근거

ORD 기록
ord-b23d4cc7af3a4edfa89c0ca1e7942988
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05574030

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