Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butanol → 1-cyclopropyl-8-(1-Bocamino-1-cyclopropyl)-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butanol | HCID 6386 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| 반응물 | 1-cyclopropyl-8-(1-hydroxycarbonyl-1-cyclopropyl)-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester | HCID 57128975 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-cyclopropyl-8-(1-Bocamino-1-cyclopropyl)-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester | HCID 57102320 | — |
반응 단계
A sample of the product from Step 477d is heated with diphenylphosphoryl azide, t-butanol, triethylamine and dioxane. The solvents is removed under vacuum. The residue is dissolved in methylene chloride, washed with water and dried over MgSO4 and concentrated under vacuum. The title compound is purified by chromatography on silica gel.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726182 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-e9a35b5778f84e018ef46a7daf51dbfd |
| 출처 메모 | uspto-grants-1998_03 |