Water → 5-[(5-Methylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

HRID 1900100노트

반응식

HRID 1900100 반응식
[CH3:1][C:2]1[O:6][C:5]([CH:7]=O)=[CH:4][CH:3]=1.[S:9]1[CH2:15][C:13](=[O:14])[NH:12][C:10]1=[S:11].C([O-])(=O)C.[Na+].O>C(O)(=O)C>[CH3:1][C:2]1[O:6][C:5]([CH:7]=[C:15]2[S:9][C:10](=[S:11])[NH:12][C:13]2=[O:14])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 120975-MethylfurfuralHCID 517045Sodium AcetateHCID 1201546Rhodanine

생성물 1

HCID 34209755-[(5-Methylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one수율 89.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 5.51 g (50.0 mmol) of 5-methylfuran-2-carboxaldehyde (purchased from Wako Junyaku Kogyo), 6.66 g (50.0 mmol) of rhodanine (purchased from Tokyo Kasei) 12.3 g (150 mmol) of anhydrous sodium acetate (purchased from Kokusan Kagaku) in 35 ml of acetic acid (purchased from Wako Junyaku Kogyo) was refluxed for 30 minutes, cooled and added to 500 ml of water, and the precipitate was collected, washed with water, ethanol and ether in order and dried to give 10.04 g (yield: 89.1%) of of (5-methylfurfurylidene)rhodanine as an orange brown crystalline.

후처리

  1. temperaturewas refluxed for 30 minutes
  2. temperaturecooled
  3. customthe precipitate was collected
  4. washwashed with water, ethanol and ether in order
  5. customdried

출처 및 근거

ORD 기록
ord-f96be1684e804958a0a5edce17092d38
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05574062

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