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Isopropanol → HCID 18796707, 화합물

HRID 1900648
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HRID 1900648 반응식
CC(O)C.C(N(CC)CC)C.[CH2:12]([O:14][C:15]([CH:17]([NH2:27])[C:18]1[CH:23]=[CH:22][C:21]2[O:24][CH2:25][O:26][C:20]=2[CH:19]=1)=[O:16])[CH3:13].Cl[C:29]1[C:38]2[C:33](=[CH:34][CH:35]=[C:36]([Cl:39])[CH:37]=2)[N:32]=[CH:31][N:30]=1>O>[CH2:12]([O:14][C:15]([CH:17]([NH:27][C:29]1[C:38]2[C:33](=[CH:34][CH:35]=[C:36]([Cl:39])[CH:37]=2)[N:32]=[CH:31][N:30]=1)[C:18]1[CH:23]=[CH:22][C:21]2[O:24][CH2:25][O:26][C:20]=2[CH:19]=1)=[O:16])[CH3:13]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 3776IsopropanolHCID 8471TriethylamineHCID 2460244,6-DichloroquinazolineHCID 3665285alpha-Ethoxycarbonyl-3,4-methylenedioxybenzylamine

생성물 1

HCID 18796707HCID 18796707, 화합물수율 85.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

30 ml of 2-propanol, 1.07 g of triethylamine and 1.01 g of α-ethoxycarbonyl-3,4-methylenedioxybenzylamine were added to 704 mg of 4,6-dichloroquinazoline. The obtained mixture was refluxed for 4 hours, followed by the addition of water. The obtained mixture was extracted with chloroform thrice. The chloroform layers were combined, dried over magnesium sulfate and distilled under a reduced pressure to remove the solvent. The residue was recrystallized (from ethanol/ethyl acetate/hexane) to give 1.167 g of the title compound.

후처리

  1. temperatureThe obtained mixture was refluxed for 4 hours
  2. extractionThe obtained mixture was extracted with chloroform thrice
  3. dry with materialdried over magnesium sulfate
  4. distillationdistilled under a reduced pressure
  5. customto remove the solvent
  6. customThe residue was recrystallized (from ethanol/ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-5e955ea7a0ab4019965ce11f0ec47c44
출처 데이터셋
uspto-grants-1996_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05576322

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