Ethyl 2-methylacetoacetate → HCID 23369854, 화합물

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[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH3:10])[CH:5]=[CH:4][C:3]=1[CH3:11].C(O[C:15](=O)[CH:16]([CH3:20])[C:17]([CH3:19])=[O:18])C.C(OCC)(=[O:24])C>CCCCCC>[CH2:9]([O:8][C:6]1[CH:5]=[CH:4][C:3]([CH3:11])=[C:2]([NH:1][C:19](=[O:24])[C:17](=[O:18])[CH:16]([CH3:20])[CH3:15])[CH:7]=1)[CH3:10]

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온도: 150 °C

실험 절차

A mixture of 2-amino-4-ethoxytoluene (590 mg, 3.99 mmol) and ethyl-2-methylacetoacetate (560 mg, 3.88 mmol) was stirred in a bath of 150° C. for 4 hours. The resultant mixture was subjected to silica gel column chromatography (developer: ethyl acetate--n-hexane), and the fraction containing the target substance was condensed, followed by recrystallizing from a solvent mixture of chloroform--n-hexane. As a result, 252 mg of the title compound was obtained as yellow powder (25.9%).