Sodium Iodide → HCID 23370065, 화합물

HRID 1901071노트

반응식

HRID 1901071 반응식
Br[CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:8]([OH:15])=[C:7]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:6]=1.[N+:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[OH:29])([O-:22])=[O:21].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>CN(C)C=O.O>[N+:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[O:29][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:8]([OH:15])=[C:7]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:6]=1)([O-:22])=[O:21]

참가 물질

7

반응물 4

HCID 5238Sodium IodideHCID 69472-NitrophenolHCID 11430Potassium CarbonateHCID 1900717Phenol, 4-(3-bromopropyl)-2,6-bis(1,1-dimethylethyl)-

생성물 1

HCID 23370065HCID 23370065, 화합물수율 74.3%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4-(3-bromopropyl)-2,6-di-t-butylphenol (1.20 g), 2-nitrophenol (0.51 g), potassium carbonate (1.01 g) and a catalytic amount of sodium iodide was stirred in dimethylformamide (10 ml) at 60°-70° C. for 1.5 hrs. The reaction solution was poured into water, extracted with ethyl acetate, washed with water and then saturated saline, and dried over anhydrous MgSO4. After distilling off the solvent, the residue was purified by a silica gel column chromatography (hexane:ethyl acetate=10:1) to give 4-[3-(2-nitrophenoxy)propyl]-2,6-di-t-butylphenol (1.05 g, 74%).

후처리

  1. extractionextracted with ethyl acetate
  2. washwashed with water
  3. dry with materialsaturated saline, and dried over anhydrous MgSO4
  4. distillationAfter distilling off the solvent
  5. customthe residue was purified by a silica gel column chromatography (hexane:ethyl acetate=10:1)

출처 및 근거

ORD 기록
ord-a1d008a519fd43189374a7c16e7ebb55
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05576335

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