Tetrabutylammonium Fluoride → 4-(3-Pyrrolyl)-7-bromocoumarin

HRID 1901130노트

반응식

HRID 1901130 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:13]3[CH:17]=[CH:16][N:15]([Si](C(C)C)(C(C)C)C(C)C)[CH:14]=3)=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[N+](CCCC)(CCCC)(CCCC)CCCC.[F-]>C1COCC1.CCOC(C)=O>[NH:15]1[CH:16]=[CH:17][C:13]([C:6]2[C:5]3[C:10](=[CH:11][C:2]([Br:1])=[CH:3][CH:4]=3)[O:9][C:8](=[O:12])[CH:7]=2)=[CH:14]1

참가 물질

5

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 23370193HCID 23370193, 화합물

생성물 1

HCID 233702084-(3-Pyrrolyl)-7-bromocoumarin

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8857Ethyl Acetate용매

실험 절차

To a solution of the silyl compound from Step 1 (42 mg, 0.094 mmol) in THF (1 mL) was added Bu4NF 1M in THF (94 (L, 0.094 mmol) and the reaction mixture was stirred at r.t. for 15 min. The mixture was diluted with EtOAc, washed with brine, dried over MgSO4, filtered and evaporated to give the title compound as an oil.

후처리

  1. washwashed with brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-9f4ea5b90d4e413d8ac8e53754a6f40e
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05576338

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