Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene → 2-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(3-fluorophenyl)ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene | HCID 241 | — |
| 반응물 | 2-Amino-1-(3-fluorophenyl)ethan-1-ol | HCID 35800 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | Methyl 4-(2-oxopropoxy)phenylacetate | HCID 21832178 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(3-fluorophenyl)ethanol | HCID 54320578 | 25.3% |
반응 단계
Following a procedure similar to that described in Example 6, but using 2 g of 2-amino-1-(3-fluorophenyl)ethanol (prepared as described in Preparation 13), 3.44 g of methyl 4-(2-oxopropoxy)phenylacetate (prepared as described in Preparation 3), 60 ml of benzene, 60 ml of absolute methanol and 3.6 g of sodium cyanoborohydride, 1.18 g of the title compound were obtained as crystals, melting at 52° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05576340 |
| 출처 데이터셋 | uspto-grants-1996_11 |
| ORD ID | ord-aae3d29f21e9493ca5b548da8b7b0d9a |
| 출처 메모 | uspto-grants-1996_11 |