Ammonia → HCID 57194161, 화합물

HRID 1901169노트

반응식

HRID 1901169 반응식
C[O:2][C:3]([CH2:5][C:6]1[CH:26]=[CH:25][C:9]([O:10][CH2:11][CH:12]([NH:14][CH2:15][CH:16]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=2)[OH:17])[CH3:13])=[C:8]([Cl:27])[CH:7]=1)=O.[NH3:28]>CO>[C:3]([CH2:5][C:6]1[CH:26]=[CH:25][C:9]([O:10][CH2:11][CH:12]([NH:14][CH2:15][CH:16]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=2)[OH:17])[CH3:13])=[C:8]([Cl:27])[CH:7]=1)(=[O:2])[NH2:28]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 218321762-[2-(4-Methoxycarbonylmethyl-2-chlorophenoxy)-1-methylethyl]amino-1-(3-chlorophenyl)ethanol

생성물 1

HCID 57194161HCID 57194161, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2 g of 2-[2-(4-methoxycarbonylmethyl-2-chlorophenoxy) -1-methylethyl]amino-1-(3-chlorophenyl)ethanol (prepared as described in Example 22) dissolved in 50 ml of methanol was saturated with gaseous ammonia in a reaction vessel, whilst ice-cooling, after which the reaction vessel was tightly stoppered and allowed to stand at room temperature for one week. At the end of this time, the solvent (methanol) was removed by distillation under reduced pressure, and the residue was recrystallized from ethyl acetate, to give 0.55 g of the title compound as crystals, melting at 99°-101° C.

후처리

  1. temperaturecooling
  2. waitto stand at room temperature for one week
  3. customAt the end of this time, the solvent (methanol) was removed by distillation under reduced pressure
  4. customthe residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-c4979ee582e84021838b5db0b01330d9
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05576340

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