Bromomethyl 4-methoxyphenyl ketone → 5-Bromo-2-(4-methoxybenzoyl)benzofuran

HRID 1901330노트

반응식

HRID 1901330 반응식
[Br:1][C:2]1[CH:9]=[C:6]([CH:7]=O)[C:5]([OH:10])=[CH:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([CH2:21]Br)=[O:20])=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:21]([C:19](=[O:20])[C:16]3[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=3)=[CH:7][C:6]=2[CH:9]=1

참가 물질

5

반응물 3

HCID 4965Bromomethyl 4-methoxyphenyl ketoneHCID 11430Potassium CarbonateHCID 728635-Bromosalicylaldehyde

생성물 1

HCID 23717245-Bromo-2-(4-methoxybenzoyl)benzofuran수율 42.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To 150 ml of acetone were suspended 20 g of 5-bromosalicylaldehyde, 22.9 g of 2-bromo-4-methoxyacetophenone and 27.6 g of anhydrous potassium carbonate. After stirring at room temperature for 4 hours, the resulting reaction solution was concentrated to dryness, and then mixed with water to collect precipitated crystals by filtration. After washing with water and subsequent recrystallization from ethanol, 14.02 g of 5-bromo-2-(4-methoxybenzoyl)benzofuran was obtained in the form of colorless prism crystals.

후처리

  1. customthe resulting reaction solution
  2. concentrationwas concentrated to dryness
  3. additionmixed with water
  4. customto collect
  5. customprecipitated crystals
  6. filtrationby filtration
  7. washAfter washing with water and subsequent recrystallization from ethanol

출처 및 근거

ORD 기록
ord-fd4f2b0f19b84a09aab15dcf1f9b02ac
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05576343

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