Acetic Acid → 3-(2-Tert-butoxycarbonylamino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole

HRID 1901599노트

반응식

HRID 1901599 반응식
C(O)(=O)C.C(O)=O.[C:8]([O:12][C:13]([N:15]1[CH:19]([CH2:20][O:21][C:22]2[C:26]3[CH:27]=[C:28]([Cl:31])[CH:29]=[CH:30][C:25]=3[O:24][N:23]=2)[CH2:18][O:17]C1(C)C)=[O:14])([CH3:11])([CH3:10])[CH3:9]>O>[C:8]([O:12][C:13]([NH:15][CH:19]([CH2:18][OH:17])[CH2:20][O:21][C:22]1[C:26]2[CH:27]=[C:28]([Cl:31])[CH:29]=[CH:30][C:25]=2[O:24][N:23]=1)=[O:14])([CH3:11])([CH3:10])[CH3:9]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 284Formic AcidHCID 23368515HCID 23368515, 화합물

생성물 1

HCID 233683553-(2-Tert-butoxycarbonylamino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole수율 80.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixed solution of 19 ml of acetic acid and 19 ml of formic acid is added 3.84 g of 3-[(3-tert-butoxycarbonyl-2,2-dimethyloxazolidin-4-yl)methoxy]-5-chloro-1,2-benzoisoxazole at 20°-25° C., and they are subjected to reaction at the same temperature for one hour. Subsequently, the reaction mixture is poured into 190 ml of water and they are stirred at the same temperature for one hour. The crystals precipitated are collected by filtration, to obtain 2.78 g of 3-(2-tert-butoxycarbonylamino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole.

후처리

  1. customthey are subjected to reaction at the same temperature for one hour
  2. customThe crystals precipitated
  3. filtrationare collected by filtration

출처 및 근거

ORD 기록
ord-4dafc90ca39c4c1aa2ea43603de346ed
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05578627

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