Methylamine → HCID 178485047, 화합물

HRID 1902281노트

반응식

HRID 1902281 반응식
[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19](=[N:22][C:23]#[N:24])SC)[N:8]=1.[CH3:28][NH2:29]>C(O)C>[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]([NH:29][CH3:28])=[N:22][C:23]#[N:24])[N:8]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 178503915HCID 178503915, 화합물

생성물 1

HCID 178485047HCID 178485047, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(3-cyano-2-methylisothioureido)butylthio]pyrimidine (0.17 g.) in 33% w/v methylamine in ethanol was left at room temperature for 18 hours and then evaporated to dryness. The residue was triturated with ether and the insoluble solid collected and recrystallised from ethyl acetate to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(2-cyano-3-methylguanidino)-butylthio]pyrimidine, m.p. 179°-180°.

후처리

  1. customevaporated to dryness
  2. customThe residue was triturated with ether
  3. customthe insoluble solid collected
  4. customrecrystallised from ethyl acetate

출처 및 근거

ORD 기록
ord-8b4d628aa18d496385354da6bf079347
출처 데이터셋
uspto-grants-1982_12
특허 번호
US04362728

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