2-(Methylthio)pyrimidin-4-amine → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-methylthiopyrimidine
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1.[F:10][C:11]([F:17])([F:16])[CH2:12][N:13]=[C:14]=[S:15]>C(#N)C>[F:10][C:11]([F:17])([F:16])[CH2:12][NH:13][C:14](=[S:15])[NH:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1참가 물질
4
실험 절차
A mixture of 4-amino-2-methylthiopyrimidine (2.1 g.), 2,2,2-trifluoroethylisothiocyanate (2.8 g.) and acetonitrile (5 ml.) was stirred at 70° for 72 hours and then cooled, and the solid that crystallised was collected to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-methylthiopyrimidine (2.15 g.) which was used without further purification.
후처리
- temperaturecooled
- customthe solid that crystallised
- customwas collected
출처 및 근거
- ORD 기록
- ord-a5a1411f1e3240088046ecbab9fa6024
- 출처 데이터셋
- uspto-grants-1982_12
- 특허 번호
- US04362728
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