m-Chloroperbenzoic acid → 2-Methylsulphinyl-4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimidine

HRID 1902291노트

반응식

HRID 1902291 반응식
ClC1C=CC=C(C(OO)=[O:9])C=1.[F:12][C:13]([F:28])([F:27])[CH2:14][N:15]=[C:16]([NH2:26])[NH:17][C:18]1[CH:23]=[CH:22][N:21]=[C:20]([S:24][CH3:25])[N:19]=1>C(O)C>[F:28][C:13]([F:12])([F:27])[CH2:14][N:15]=[C:16]([NH2:26])[NH:17][C:18]1[CH:23]=[CH:22][N:21]=[C:20]([S:24]([CH3:25])=[O:9])[N:19]=1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 212798084-[2-(2,2,2-Trifluoroethyl)guanidino]-2-methylthiopyrimidine

생성물 1

HCID 212797752-Methylsulphinyl-4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimidine수율 94.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3-Chloroperbenzoic acid (0.8 g.) was added to a solution of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-methylthiopyrimidine (0.5 g.) in ethanol (50 ml.) and the solution left at room temperature for 18 hours and then evaporated to dryness. The residue was dissolved in ethyl acetate, the solution washed with aqueous potassium carbonate solution and then dried and evaporated to dryness to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-methylsulphinylpyrimidine (0.5 g.) which was used without further purification.

후처리

  1. customevaporated to dryness
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washthe solution washed with aqueous potassium carbonate solution
  4. customdried
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-a5ed9a1631d540379da3e0d1cdee0215
출처 데이터셋
uspto-grants-1982_12
특허 번호
US04362728

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