Benzaldehyde → 3-(1H-Benzimidazol-1-yl)-N-benzylpropan-1-amine

HRID 1902459노트

반응식

HRID 1902459 반응식
[H][H].[N:3]1([CH2:12][CH2:13][CH2:14][NH2:15])[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[N:5]=[CH:4]1.[CH:16](=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>[Pd].C(O)C>[CH2:16]([NH:15][CH2:14][CH2:13][CH2:12][N:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[N:5]=[CH:4]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

6

반응물 3

HCID 240BenzaldehydeHCID 39208493-(1H-1,3-benzodiazol-1-yl)propan-1-amineHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 204690543-(1H-Benzimidazol-1-yl)-N-benzylpropan-1-amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매2회

실험 절차

0.5 Gram of 10% palladium on charcoal was prehydrogenated in 100 ml. of absolute ethanol until the uptake of hydrogen stopped. Then, a solution of 10 grams of 1H-benzimidazole-1-propanamine and 6.7 grams of benzaldehyde in 50 ml. of absolute ethanol was added and the mixture was stirred at atmospheric pressure and room temperature under hydrogen until the calculated amount of hydrogen was taken up. The catalyst was then removed by filtration and the solvent was evaporated to leave N-benzyl-1H-benzimidazole-1-propanamine as a colorless oil. This material was sufficiently pure for further reaction but, if desired, a pure sample could be obtained by column chromatography on silica gel.

후처리

  1. customThe catalyst was then removed by filtration
  2. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-5ab23850e9a44aa79a3e87306aef8c55
출처 데이터셋
uspto-grants-1982_12
특허 번호
US04363808

반응 노트

불러오는 중…