Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetyl chloride → 4-Chloroacetyl-1,3-dimethyl-1,4,9,10-tetrahydropyrrolo[3,2-b][1,5]benzodiazepin-10-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,3-Dimethyl-1,4,9,10-tetrahydropyrrolo[3,2-b][1,5]benzodiazepin-10-one | HCID 18975980 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-Chloroacetyl-1,3-dimethyl-1,4,9,10-tetrahydropyrrolo[3,2-b][1,5]benzodiazepin-10-one | HCID 20261504 | 69% |
반응 단계
A solution of 1.47 g of chloroacetyl chloride in 20 ml of dioxane is added dropwise with stirring to 1.9 g of 1,3-dimethyl-1,4,9,10-tetrahydropyrrolo[3,2-b][1,5]benzodiazepin-10-one, 5.5 g of powdered anhydrous potassium carbonate and 50 ml of dioxane in the course of 10 minutes at 50° C. The obtained mixture is stirred for several hours; precipitate is then filtered off, and the filtrate is concentrated to dryness. 1.75 g (69%) of the title compound of m.p. 267° to 269° C. (from acetonitrile) are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04363816 |
| 출처 데이터셋 | uspto-grants-1982_12 |
| ORD ID | ord-dd052bbb04f44f4eb700aa12e0d99d9f |
| 출처 메모 | uspto-grants-1982_12 |