3-Chloro-1-propanol → 3-[3-(Dimethylamino)phenoxy]propan-1-ol

반응식

[Na].[CH3:2][N:3]([CH3:11])[C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1.Cl[CH2:13][CH2:14][CH2:15][OH:16]>>[CH3:2][N:3]([CH3:11])[C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[O:10][CH2:13][CH2:14][CH2:15][OH:16]

참가 물질

반응물 2

HCID 123133-Chloro-1-propanol

HCID 70552614HCID 70552614, 화합물

생성물 1

HCID 30190163-[3-(Dimethylamino)phenoxy]propan-1-ol수율 57%

실험 절차

Preparation analogously to Example 70 by the reaction of 3-dimethylaminophenol sodium salt with 3-chloro-1-propanol to give 3-(3-dimethylaminophenoxy)-1-propanol (b.p.0.7 =150°-5°; yield 57%), which is converted quantitatively into 3-(3-dimethylaminophenoxy)-propyl 1-methanesulphonate (oil) and is reacted with excess 5-amino-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate in boiling ethanol. Isolation as hydrochloride. Yield, after recrystallisation from ethanol+active charcoal: 38.2%.

후처리

customPreparation analogously to Example 70

출처 및 근거

ORD 기록: ord-655fb93409cf4be0bb500d063963267a
출처 데이터셋: uspto-grants-1982_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04363805

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