2,3-Dihydro-6-nitroimidazo(2,1-b)benzothiazole → 2,3-Dihydroimidazo(2,1-b)benzothiazol-6-amine

HRID 1902632노트

반응식

HRID 1902632 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]3=[N:12][CH2:13][CH2:14][N:9]3[C:8]=2[CH:15]=1)([O-])=O.[H][H]>[Pd].CO>[N:12]1[CH2:13][CH2:14][N:9]2[C:8]3[CH:15]=[C:4]([NH2:1])[CH:5]=[CH:6][C:7]=3[S:11][C:10]=12

참가 물질

5

반응물 2

HCID 128919642,3-Dihydro-6-nitroimidazo(2,1-b)benzothiazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 6586872,3-Dihydroimidazo(2,1-b)benzothiazol-6-amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 11 parts of 2,3-dihydro-6-nitroimidazo[2,1-b]benzothiazole and 80 parts of methanol is hydrogenated at normal pressure and at room temperature with 5 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is crystallized from dimethylbenzene. The product is filtered off and dried, yielding 5.6 parts of 2,3-dihydroimidazo[2,1-b]benzothiazol-6-amine; mp. 204°-210° C.

후처리

  1. filtrationthe catalyst is filtered off
  2. customthe filtrate is evaporated
  3. customThe residue is crystallized from dimethylbenzene
  4. filtrationThe product is filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-0ed93e7ccc5147569caf7196be0e10fc
출처 데이터셋
uspto-grants-1982_12
특허 번호
US04364942

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