Prednisolone → 11beta,17-Dihydroxy-21-methoxyacetoxy-1,4-pregnadiene-3,20-dione

HRID 1903054

반응식

HRID 1903054 반응식
[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:24])[C:17](=[O:20])[CH2:18][OH:19])[C@H:12]2[C@H:3]1[C@:4]1([CH3:26])[C:9]([CH2:10][CH2:11]2)=[CH:8][C:7](=[O:25])[CH:6]=[CH:5]1.[CH3:27][O:28][CH2:29][C:30](Cl)=[O:31]>N1C=CC=CC=1>[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:24])[C:17](=[O:20])[CH2:18][O:19][C:30](=[O:31])[CH2:29][O:28][CH3:27])[C@H:12]2[C@H:3]1[C@:4]1([CH3:26])[C:9]([CH2:10][CH2:11]2)=[CH:8][C:7](=[O:25])[CH:6]=[CH:5]1

참가 물질

4

반응물 2

HCID 5755PrednisoloneHCID 96623Methoxyacetyl chloride

생성물 1

HCID 5661399311beta,17-Dihydroxy-21-methoxyacetoxy-1,4-pregnadiene-3,20-dione

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 10.0 g of 11β,17,21-trihydroxy-1,4-pregnadiene-3,20-dione in pyridine is reacted analogously to Example 1(a) with methoxyacetic acid chloride, worked up, and purified, thus isolating 10.3 g of 11β,17-dihydroxy-21-methoxyacetoxy-1,4-pregnadiene-3,20-dione.

후처리

  1. custompurified

출처 및 근거

ORD 기록
ord-3abc6e147f7a4e7f835636401458d6ea
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04435390

연결된 노트

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