Methylprednisolone → 11beta,17-Dihydroxy-6alpha-methyl-21-(3-methoxypropionyloxy)-1,4-pregnadiene-3,20-dione

HRID 1903059노트

반응식

[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:24])[C:17](=[O:20])[CH2:18][OH:19])[C@H:12]2[C@H:3]1[C@:4]1([CH3:27])[C:9]([C@@H:10]([CH3:25])[CH2:11]2)=[CH:8][C:7](=[O:26])[CH:6]=[CH:5]1.[CH3:28][O:29][CH2:30][CH2:31][C:32](Cl)=[O:33]>>[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:24])[C:17](=[O:20])[CH2:18][O:19][C:32](=[O:33])[CH2:31][CH2:30][O:29][CH3:28])[C@H:12]2[C@H:3]1[C@:4]1([CH3:27])[C:9]([C@@H:10]([CH3:25])[CH2:11]2)=[CH:8][C:7](=[O:26])[CH:6]=[CH:5]1

참가 물질

반응물 2

HCID 6741Methylprednisolone

HCID 27597283-Methoxypropanoyl chloride

생성물 1

HCID 5662029311beta,17-Dihydroxy-6alpha-methyl-21-(3-methoxypropionyloxy)-1,4-pregnadiene-3,20-dione

실험 절차

Under the conditions of Example 3(a), 15.0 g of 11β,17,21-trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione is reacted with 3-methoxypropionic acid chloride, worked up, and purified, thus isolating 14.3 g of 11β,17-dihydroxy-6α-methyl-21-(3-methoxypropionyloxy)-1,4-pregnadiene-3,20-dione, mp 230° C.

후처리

custompurified

출처 및 근거

ORD 기록: ord-798436e653864e28a3f8301899f6db16
출처 데이터셋: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04435390

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