Triethylamine → 6-Chloro-5-methyl-4-[2-(2-methyl-4-n-pentylphenoxy)ethylamino]pyrimidine

HRID 1903132노트

반응식

HRID 1903132 반응식
Cl[C:2]1[C:7]([CH3:8])=[C:6]([Cl:9])[N:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[CH3:17][C:18]1[CH:27]=[C:26]([CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH:25]=[CH:24][C:19]=1[O:20][CH2:21][CH2:22][NH2:23]>C1(C)C=CC=CC=1>[Cl:9][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:23][CH2:22][CH2:21][O:20][C:19]2[CH:24]=[CH:25][C:26]([CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[CH:27][C:18]=2[CH3:17])[C:7]=1[CH3:8]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 8188604,6-Dichloro-5-methylpyrimidineHCID 155880312-(2-Methyl-4-pentylphenoxy)ethylamine

생성물 1

HCID 130754626-Chloro-5-methyl-4-[2-(2-methyl-4-n-pentylphenoxy)ethylamino]pyrimidine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 3.2 g (0.02 mol) of 4,6-dichloro-5-methylpyrimidine in 50 ml of toluene were added 2.0 g (0.02 mol) of triethylamine and 4.4 g (0.02 mol) of 2-(2-methyl-4-n-pentylphenoxy)ethylamine. The mixture was then refluxed with stirring for 5 hours.

후처리

  1. temperatureThe mixture was then refluxed

출처 및 근거

ORD 기록
ord-d8e373fc8b09465d848e2d12e6c5f9b6
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04435402

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