HCID 13273322, 화합물 → 2-(Difluoromethyl)hex-5-enoic acid
반응식
[C:1]([C:4]([CH:12]([F:14])[F:13])([CH2:8][CH2:9][CH:10]=[CH2:11])C(O)=O)([OH:3])=[O:2]>C(O)(=O)C>[F:13][CH:12]([F:14])[CH:4]([CH2:8][CH2:9][CH:10]=[CH2:11])[C:1]([OH:3])=[O:2]참가 물질
3
반응 조건
- 온도
- 110 °C
실험 절차
2-Carboxy 2-difluoromethyl 5-hexenoic acid, prepared as in Step C (1.040 g, 5 mM) is dissolved in glacial acetic acid (5 ml) and the mixture is heated at 110° C. for 16 hours. The solvent is evaporated in vacuo yielding a colorless oil. The acid is isolated by distillation under reduced pressure. 0.585 g (yield 71%). Bp: 67° C./0.01 mm Hg.
후처리
- customThe solvent is evaporated in vacuo
- customyielding a colorless oil
- customThe acid is isolated by distillation under reduced pressure
출처 및 근거
- ORD 기록
- ord-a910656b234743efa0dc2c514ab18484
- 출처 데이터셋
- uspto-grants-1984_03
- 특허 번호
- US04435425
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