Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Chloride → 3-((tert-Butoxycarbonyl)amino)-4,4-difluorobutanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Pyrocarbonate | HCID 15238643 | — |
| 반응물 | 3-Amino-4,4-difluorobutanoic acid hydrochloride | HCID 71403098 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-((tert-Butoxycarbonyl)amino)-4,4-difluorobutanoic acid | HCID 20468453 | — |
반응 단계
A mixture of 4,4-difluoro-3-amino-butanoic acid, hydrochloride prepared as in Step C (0.702 g, 4 mM), ditertiobutyl dicarbonate (0.916 g, 4.2 mM), sodium bicarbonate (0.336 g, 4 mM) in tetrahydrofuran and water (6 ml of a 1:1 mixture) is heated at reflux for 48 hours. The resulting solution is saturated with sodium chloride and extracted three times with chloroform. The organic phase is dried over anhydrous magnesium sulfate, and the solvent evaporated in vacuo yielding a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04435425 |
| 출처 데이터셋 | uspto-grants-1984_03 |
| ORD ID | ord-e51cfa98c7f84b508c523cc99e55a595 |
| 출처 메모 | uspto-grants-1984_03 |