Ethanolamine → 1-(2-Hydroxyethyl)-3-phenylurea

HRID 1903289

반응식

HRID 1903289 반응식
[CH2:1]([CH2:3][NH2:4])[OH:2].[SH2]=N.[C:7]1([NH:13][C:14](C2C=CC=CC=2C(O)=O)=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CC(C)=O>[C:7]1([NH:13][C:14]([NH:4][CH2:3][CH2:1][OH:2])=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 700EthanolamineHCID 178514671HCID 178514671, 화합물

생성물 1

HCID 773521-(2-Hydroxyethyl)-3-phenylurea수율 26.9%

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

A solution of 0.65 g ethanolamine with 5 ml aceton was added dropwise to a suspension of 1.5 g phenylcarbamoyl-benzoic acid sulfimide with 10 ml aceton, under stirring. The reaction mixture was stirred for a further 30 minutes at ambient temperature, evaporated in vacuo, the residue was triturated with 20 ml water, and the obtained solid product was filtered, dried and recrystallized. There was obtained 0.25 g 1-phenyl-3-(2-hydroxyethyl)-urea, melting at 120°-122° C.

후처리

  1. stirringThe reaction mixture was stirred for a further 30 minutes at ambient temperature
  2. customevaporated in vacuo
  3. customthe residue was triturated with 20 ml water
  4. filtrationthe obtained solid product was filtered
  5. customdried
  6. customrecrystallized

출처 및 근거

ORD 기록
ord-6a4bc0185b8a4f68ba06f1ee91d1b5f7
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04435567

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