Acetone → N-Phenyl-N'-2-pyridinylurea

HRID 1903293노트

반응식

HRID 1903293 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(N(CC)CC)C.CC(C)=O.[SH2]=N.[C:21]1([NH:27][C:28](C2C=CC=CC=2C(O)=O)=[O:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>O>[C:21]1([NH:27][C:28]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=2)=[O:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

6

반응물 4

HCID 180Acetone2회HCID 8471TriethylamineHCID 104392-AminopyridineHCID 178514671HCID 178514671, 화합물

생성물 1

HCID 221427N-Phenyl-N'-2-pyridinylurea수율 54.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 0.5 g aminopyridin and 0.7 ml triethylamine with 5 ml acetone was added dropwise to a suspension of 1.5 g phenylcarbamoyl-benzoic acid sulfimide with 15 ml aceton, under stirring. The reaction mixture was stirred for 45 minutes at room temperature, then diluted with 100 ml water. The acetone was distilled off, the residue was cooled, and the precipitated solid product was filtered, washed with water and dried. 0.6 g 1-phenyl-3-(2-pyridyl)-urea was obtained with a melting point of 185°-186° C.

후처리

  1. stirringThe reaction mixture was stirred for 45 minutes at room temperature
  2. distillationThe acetone was distilled off
  3. temperaturethe residue was cooled
  4. filtrationthe precipitated solid product was filtered
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-68a5453750874c93b78d6537cfc727aa
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04435567

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