Phosgene → Iminostilbene N-carbonylchloride

반응식

[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[NH:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:16](Cl)([Cl:18])=[O:17]>>[Cl:18][C:16]([N:6]1[C:7]2[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=2[CH:9]=[CH:10][C:11]2[CH:1]=[CH:2][CH:3]=[CH:4][C:5]1=2)=[O:17]

참가 물질

반응물 2

HCID 6371Phosgene

HCID 9212Dibenz(b,f)azepine

생성물 1

HCID 182151Iminostilbene N-carbonylchloride

실험 절차

There is known from the German Patent Specification No. 1,136,707 a process for producing 5H-dibenz[b,f]azepine-5-carboxamide by reaction of 5H-dibenz[b,f]azepine with phosgene to give 5-chlorocarbonyl-5H-dibenz[b,f]azepine and the subsequent reaction thereof with ammonia to obtain the stated compound. The reaction of 5H-dibenz[b,f]azepine with phosgene is performed in toluene firstly at 70° C., and then under reflux. The subsequent reaction of this compound with ammonia is carried out in ethanol at boiling temperature.

출처 및 근거

ORD 기록: ord-532fa3ec7fbd4ed0820d812ca85f312d
출처 데이터셋: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04436660

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