p-Toluenesulfonic acid → Ethyl 4-oxotetrahydrothiophene-3-carboxylate

HRID 1903639노트

반응식

HRID 1903639 반응식
[O:1]=[C:2]1[CH:6]([C:7]([O:9][CH3:10])=[O:8])[CH2:5][S:4][CH2:3]1.[C:11]1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)C>[O:1]=[C:2]1[CH:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:5][S:4][CH2:3]1

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester

생성물 1

HCID 310629Ethyl 4-oxotetrahydrothiophene-3-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

20 parts by weight of methyl 3-keto-1,5-dihydrothiophene-4-carboxylate, 57.8 parts by weight of ethanol and 1 part by weight of p-toluenesulfonic acid are refluxed for 50 hours, and the mixture is then distilled. 17.1 parts by weight of ethyl 3-keto-1,5-dihydrothiophene-4-carboxylate of melting point 106°-109° C./1.3 mbar are obtained.

후처리

  1. distillationthe mixture is then distilled

출처 및 근거

ORD 기록
ord-39f68d43f51041e3867a14821280d6d7
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04437878

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