Phosgene → 3-(3-Phenylpropyl)phenyl isocyanate

HRID 1903653

반응식

HRID 1903653 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]([CH:14]=[CH:15][CH:16]=2)[NH2:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:17](Cl)(Cl)=[O:18]>C1(C)C=CC=CC=1>[C:1]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]([N:13]=[C:17]=[O:18])[CH:14]=[CH:15][CH:16]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 6371PhosgeneHCID 4273073-(3-Phenylpropyl)aniline

생성물 1

HCID 127905743-(3-Phenylpropyl)phenyl isocyanate수율 89%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

To a solution of 3-(3-phenylpropyl)aniline (11.6 g) in 100 ml of toluene was dropwise added a solution of phosgene (20 g) in 100 ml of toluene at 10°-20° C. The resultant mixture was gradually heated and, after refluxed for 30 minutes, allowed to cool to room temperature. The solvent was removed under reduced pressure, and the residue was distilled under reduced pressure to give 11.6 g of 3-(3-phenylpropyl)phenyl isocyanate (yield, 89%). B.P. 121°-125° C./0.2 mmHg.

후처리

  1. temperatureafter refluxed for 30 minutes
  2. customThe solvent was removed under reduced pressure
  3. distillationthe residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-2b1085577a094030a811874d9fb02bcd
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04437880

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