Nitric Acid → 1,4-Dichloro-2-cyclohexyl-5-nitrobenzene

HRID 1903734

반응식

HRID 1903734 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1.S(=O)(=O)(O)O.[N+:20]([O-])([OH:22])=[O:21]>>[Cl:1][C:2]1[CH:7]=[C:6]([N+:20]([O-:22])=[O:21])[C:5]([Cl:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric Acid2회HCID 130971441,4-Dichloro-2-cyclohexylbenzene

생성물 1

HCID 130971451,4-Dichloro-2-cyclohexyl-5-nitrobenzene

실험 절차

To a solution of 1,4-dichloro-2-cyclohexylbenzene (12.0 g) in conc.sulfuric acid (15 ml) was added dropwise a mixture of nitric acid (d=1.42, 4 ml) and conc.sulfuric acid (6 ml) with stirring under ice-cooling. After the stirring was continued for 10 minutes, ice-water was added to the reaction mixture to give an oily residue, which was extracted with ether, washed with water, dried over magnesium sulfate and concentrated under reduced pressure. The resultant oily residue was distilled under reduced pressure to give 1,4-dichloro-2-cyclohexyl-5-nitrobenzene (10.0 g).

후처리

  1. temperaturecooling
  2. customto give an oily residue, which
  3. extractionwas extracted with ether
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. distillationThe resultant oily residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-2155171f4ae94ad5852a801fb143ba25
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04438126

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