참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 2,6-Difluoro-alpha-methylbenzyl alcohol | HCID 5012075 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 2-(1-Chloroethyl)-1,3-difluorobenzene | HCID 588055 | 99.8% |
반응 단계
2,6-Difluoro-alpha-methylbenzyl alcohol of (B) (14.9 g, 0.094 mol) is dissolved in chloroform (50 ml) and warmed to 60° C. Thionyl chloride (22.4 g, 0.19 mol) is now added dropwise. The whole is kept at 60° C. for 4 hours then stirred overnight at room temperature. Excess thionyl chloride and chloroform are then removed on a rotary evaporator, resulting in pure title product (16.6 g, 99.8%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04438271 |
|---|
| 출처 데이터셋 | uspto-grants-1984_03 |
|---|
| ORD ID | ord-05eb1a4e6dd5472fb76ab7ef7c7bbbc6 |
|---|
| 출처 메모 | uspto-grants-1984_03 |
|---|
