Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → alpha-(Difluoromethyl)arginine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ornithine, 2-(difluoromethyl)-, hydrochloride, hydrate (1:1:1) | HCID 441361 | — |
| 반응물 | [amino(sulfanyl)methylidene]-ethylazanium;hydrobromide | HCID 178419565 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | alpha-(Difluoromethyl)arginine | HCID 178512962 | — |
반응 단계
To a solution of 2-difluoromethyl-2,5-diamino-pentanoic acid monohydrate monohydrochloride (5 g or 21.13 mmole) in NaOH 2M (8.5 ml) is added at once ethylthiouronium hydrobromide (7.82 g or 42.26 mmole). The pH of the solution is adjusted to 10.5 with NaOH 2M and maintained to that value for 4 days. The reaction mixture is then neutralized to pH=7 with 1 M HCl and concentrated under reduced pressure. The residue is passed on an Amberlite IR 120 H+ form column. Elution with NH4OH 2 M affords 2-difluoromethyl-2-amino-5-guanidinopentanoic acid which is recrystallized from H2O/EtOH (2.3 g) m.p. 257° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04438270 |
| 출처 데이터셋 | uspto-grants-1984_03 |
| ORD ID | ord-41be927ef3f540cf8ae7a87cadd441eb |
| 출처 메모 | uspto-grants-1984_03 |