Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-one → 2-[4-(4-Dimethylaminomethyl-2-pyridyl)butylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-one | HCID 3018360 | — |
| 반응물 | 4-(4-Dimethylaminomethyl-2-pyridyl)butylamine | HCID 20239072 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 2-[4-(4-Dimethylaminomethyl-2-pyridyl)butylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone | HCID 13292608 | 43.9% |
반응 단계
A mixture of 4-(4-dimethylaminomethyl-2-pyridyl)butylamine (1 g) and 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone (1.26 g) in pyridine (5 ml) was refluxed for 4.5 hours. The solvent was removed in vacuo, the residue chromatographed and then crystallised from ethanol:ether (1:10) to yield 2-[4-(4-dimethylaminomethyl-2-pyridyl)butylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone (0.86 g) m.p. 135°-137°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04439609 |
| 출처 데이터셋 | uspto-grants-1984_03 |
| ORD ID | ord-13ccc3816d6e47409c52aaabe7b0b35c |
| 출처 메모 | uspto-grants-1984_03 |