참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Heptanenitrile, 7-bromo- | HCID 88737 | — |
| 반응물 | 2,2'-[iminobis(ethane-2,1-diyl)]bis(1H-isoindole-1,3(2H)-dione) | HCID 354707 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (6-Cyanohexyl)bis(2-phthalimidoethyl)amine | HCID 19811078 | 41% |
반응 단계
A mixture of 6-bromohexylcyanide (13.88g, 0.073 mol), bis(2-phthalimidoethyl)amine (26.52g, 0.073 mol), and triethylamine (7.37g, 0.073 mol) in DMF (120 ml) was heated at 100° C. for 20 hours. After cooling, the precipitate which had formed was removed by filtration and the filtrate was poured into ice (1000 ml). The aqueous solution was extracted with dichloromethane (3×200 ml). The combined organic extracts were washed with brine and dried over Na2SO4. Removal of the solvent under reduced pressure gave crude product which was chromatographed on silica gel (hexanes - 30% ethyl acetate/hexanes gradient elution). Impure fractions were rechromatographed to provide a total of 14.1g of (6-cyanohexyl)bis(2-phthalimidoethyl)amine (41%) as an oil. The produce was one spot on tlc. The ir spectrum was consistent with the assigned structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04837003 |
|---|
| 출처 데이터셋 | uspto-grants-1989_06 |
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| ORD ID | ord-483dd1139f19449084535fe7a6099335 |
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| 출처 메모 | uspto-grants-1989_06 |
|---|
