Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenyl isocyanate → N-(3-Phenylcarbamoylthio-2-methyl-propanoyl)-N-cyclopentyl glycine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenyl isocyanate | HCID 7672 | — |
| 반응물 | (S)-[Cyclopentyl-(3-mercapto-2-methyl-propionyl)-amino]-acetic acid | HCID 13469595 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(3-Phenylcarbamoylthio-2-methyl-propanoyl)-N-cyclopentyl glycine | HCID 13469596 | — |
반응 단계
A mixture of 4.9 g (0.02M) of N-(3-mercapto-2-methyl propanoyl)-N-cyclopentyl glycine and 8 ml of phenyl isocyanate in 5 ml methylene chloride was stirred at room temperature for 72 hours. The mixture was diluted with ether and filtered. The ether solution was washed with water, dried over MgSO4 and evaporated to dryness. The crude residue was dissolved in acetonitrile, treated with charcoal and crystallized by addition of ether, m.p. 170°-172° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04839367 |
| 출처 데이터셋 | uspto-grants-1989_06 |
| ORD ID | ord-4e4353bd8f7547899d389454002556e5 |
| 출처 메모 | uspto-grants-1989_06 |