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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Ammonium Chloride → 1-Acridinol, 1,2,3,4-tetrahydro-9-(((4-(trifluoromethyl)phenyl)methyl)amino)-

HRID 1904740
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HRID 1904740 반응식
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:25]=[CH:24][C:6]([CH2:7][NH:8][C:9]2[C:10]3[C:15]([N:16]=[C:17]4[C:22]=2[C:21](=[O:23])[CH2:20][CH2:19][CH2:18]4)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:5][CH:4]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[Cl-].[NH4+]>C1COCC1>[F:26][C:2]([F:1])([F:27])[C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][C:9]2[C:10]3[C:15]([N:16]=[C:17]4[C:22]=2[CH:21]([OH:23])[CH2:20][CH2:19][CH2:18]4)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:24][CH:25]=1
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참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 13935143HCID 13935143, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 30256271-Acridinol, 1,2,3,4-tetrahydro-9-(((4-(trifluoromethyl)phenyl)methyl)amino)-수율 76.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

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온도
10 °C

실험 절차

In 100 ml of dry THF was dissolved 2.49 g of 3,4-dihydro-9-(4-trifluoromethylbenzylamino)acridin-1(2H)-one. The mechanically stirred solution was cooled under nitrogen to 10° C. and 3.4 ml of 1M LiAlH4 in THF was added dropwise over 10 minutes. AFter 1/2 hour of stirring, the reaction was complete. It was neutralized with 1 ml of saturated ammonium chloride solution and the resulting salts were filtered. The filtrate was evaporated to a solid which was recrystallized from 1:1 dichloromethane/pentane to yield 1.91 g of solid, mp 174°-176° C.

후처리

  1. filtrationthe resulting salts were filtered
  2. customThe filtrate was evaporated to a solid which
  3. customwas recrystallized from 1:1 dichloromethane/pentane

출처 및 근거

ORD 기록
ord-e12cc310180348cd8971430bcafd79fc
출처 데이터셋
uspto-grants-1989_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04839364

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