Ammonia → 1-(4-Aminophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione

HRID 1904789노트

반응식

HRID 1904789 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:14]([OH:16])=O)[CH2:10][CH:9]2[C:11](O)=[O:12])=[CH:4][CH:3]=1.[NH3:17]>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]23[CH2:10][CH:9]2[C:11](=[O:12])[NH:17][C:14]3=[O:16])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 200380431-(4-Aminophenyl)-1,2-cyclopropanedicarboxylic acid

생성물 1

HCID 140689341-(4-Aminophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione

실험 절차

In a glass bomb tube, 2.3 g of 1-(4-aminophenyl)-1,2-cyclopropanedicarboxylic acid are stirred in 80 ml of approx. 1N methanolic ammonia solution for 7 days at 100° C. The reaction mixture is evaporated to dryness and the residue is chromatographed over silica gel with hexane/ethyl acetate (4:6). Recrystallisation from ethanol affords white crystals of the title compound, which is identical with the title compound of Example 1.

후처리

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue is chromatographed over silica gel with hexane/ethyl acetate (4:6)
  3. customRecrystallisation from ethanol

출처 및 근거

ORD 기록
ord-6909bc20c31c4a9f8a89c4819f518c19
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04839379

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