3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole → CH-13584

HRID 1904904

반응식

HRID 1904904 반응식
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12].[Na].Cl[CH2:15][C:16]1[N:20]=[C:19]([CH3:21])[O:18][N:17]=1>CN(C)C=O>[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:15][C:16]3[N:20]=[C:19]([CH3:21])[O:18][N:17]=3)[C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12]

참가 물질

4

반응물 2

HCID 3021573-(Chloromethyl)-5-methyl-1,2,4-oxadiazoleHCID 678245293-Methylxanthine sodium

생성물 1

HCID 163975CH-13584수율 71%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

A mixture of 3.76 g of (20 millimoles) of 3-methylxanthine-sodium, 100 ml of dimethyl formamide and 2.60 g (19.6 millimoles) of 3-chloromethyl-5-methyl-1,2,4-oxadiazole is stirred at 100° C. for one hour and a half. The hot reaction mixture is filtered and to the filtrate 50 ml of methanol are added. Thus 3.65 g of 3,7-dihydro-3-methyl-7-([5-methyl-1,2,4-oxadiazole-3-yl]-methyl)-1H-purine-2,6-dione are obtained, m.p.: 262°-264° C. Yield: 69%.

후처리

  1. filtrationThe hot reaction mixture is filtered and to the filtrate 50 ml of methanol
  2. additionare added

출처 및 근거

ORD 기록
ord-28789e223b2a40099c9f59ef8492b21e
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04840949

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