Triethylamine → 5-Et-ddU

HRID 1905001노트

반응식

HRID 1905001 반응식
[CH2:1]([C:3]1[C:4](=[O:18])[NH:5][C:6](=[O:17])[N:7]([CH:16]=1)[C@@H:8]1[O:14][C@H:11]([CH2:12][OH:13])[C@@H:10](I)[CH2:9]1)[CH3:2].C(N(CC)CC)C.[H][H]>CO.[Pd]>[CH2:1]([C:3]1[C:4](=[O:18])[NH:5][C:6](=[O:17])[N:7]([CH:16]=1)[C@@H:8]1[O:14][C@H:11]([CH2:12][OH:13])[CH2:10][CH2:9]1)[CH3:2]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 451824Uridine, 2',3'-dideoxy-5-ethyl-3'-iodo-HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 4514525-Et-ddU수율 75%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

5-Ethyl-3'-iodo-2',3'-dideoxyuridine (432 mg, 0.87 mmole) is dissolved in methanol (40 ml) and triethylamine (0.5 ml) is added along with 10% Pd/C (200 mg). The mixture is then stirred in an atmosphere of hydrogen at room temperature for 30 min. After filtration of catalyst, the filtrate is evaporated to dryness. Purification of the product was achieved on silica gel plates using chloroform-methanol (20:1) to obtain a solid (150 mg, 75%).

후처리

  1. filtrationAfter filtration of catalyst
  2. customthe filtrate is evaporated to dryness
  3. customPurification of the product

출처 및 근거

ORD 기록
ord-991fd344f4d4424fb25bac519567c26f
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04841039

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