6-[4-(2-t-butoxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone → 6-[4-(2-amino-2-methylpropyl amino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

HRID 1905416노트

반응식

HRID 1905416 반응식
C(OC([NH:8][C:9]([CH3:27])([CH3:26])[CH2:10][NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]([CH3:25])[CH2:20][C:21](=[O:24])[NH:22][N:23]=2)=[CH:14][CH:13]=1)=O)(C)(C)C.C(OCC)(=O)C.Cl>C(OCC)(=O)C>[NH2:8][C:9]([CH3:26])([CH3:27])[CH2:10][NH:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:19]([CH3:25])[CH2:20][C:21](=[O:24])[NH:22][N:23]=2)=[CH:16][CH:17]=1

참가 물질

4

반응물 2

HCID 108332506-[4-(2-t-butoxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinoneHCID 21866389Hydrogen chloride-ethyl acetate

생성물 1

HCID 106123876-[4-(2-amino-2-methylpropyl amino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone수율 75.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The 6-[4-(2-t-butoxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (3.74 g) obtained in (1-c) above was dissolved in ethyl acetate (10 ml), and 15% hydrogen chloride-ethyl acetate solution (40 ml) was added. The mixture was stirred for 2 hours, and the solvent was evaporated under reduced pressure. The residue was dissolved in water, made alkaline with sodium carbonate, and extracted with chloroform. The extract was dried over MgSO4, and the solvent was evaporated to give 6-[4-(2-amino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (2.06 g).

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with chloroform
  4. dry with materialThe extract was dried over MgSO4
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-1da59c6e06b340ceb817b9d8b21d183b
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04843072

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