Ammonia → HCID 20144953, 화합물

반응식

[CH3:1][NH:2][C:3]1[S:4][C:5]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[C:6]([C:8](OCC)=[O:9])[N:7]=1.[NH3:19]>>[C:8]([C:6]1[N:7]=[C:3]([NH:2][CH3:1])[S:4][C:5]=1[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)(=[O:9])[NH2:19]

참가 물질

반응물 2

HCID 222Ammonia

HCID 20145031HCID 20145031, 화합물

생성물 1

HCID 20144953HCID 20144953, 화합물

실험 절차

A solution of ethyl 2-methylamino-5-(4-pyridyl)-4-thiazolecarboxylate (2.36 g) in 26% methanolic ammonia (100 ml) was allowed to stand at ambient temperature for 5 days. The reaction mixture was evaporated in vacuo and the residue was washed with tetrahydrofuran to give 4-carbamoyl-2-methylamino-5-(4-pyridyl)thiazole (1.0 g). mp 212°-213° C. (from tetrahydrofuran-methanol).

후처리

customThe reaction mixture was evaporated in vacuo
washthe residue was washed with tetrahydrofuran

출처 및 근거

ORD 기록: ord-158deac0235946bfa7cc961262284a17
출처 데이터셋: uspto-grants-1987_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04649146

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