5-Chloro-2(1H)-pyrimidinone → HCID 12791252, 화합물

HRID 1906158노트

반응식

HRID 1906158 반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH2:10][C:11]([C:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[NH:15][CH:14]=1)=[O:12]>C(N(CC)CC)C.C(O)C>[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[N:6]([CH2:10][C:11]([C:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)=[O:12])[CH:7]=1

참가 물질

5

반응물 2

HCID 1085785-Chloro-2(1H)-pyrimidinoneHCID 113109362-bromo-1-(1H-indol-3-yl)ethanone

생성물 1

HCID 12791252HCID 12791252, 화합물수율 57.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8471Triethylamine용매

실험 절차

A mixture of 5-chloropyrimidin-2-one (522 mg) and 3-bromoacetylindole (1.19 g) in triethylamine (0.84 ml) and ethanol (25 ml) was stirred at room temperature. After 1.5 h the mixture was heated to 55° C. After a further 1.5 h the mixture was cooled and the resulting precipitate collected and washed with cold ethanol. Recrystallisation twice from ethyl acetate and once from ethanol gave the title pyrimidinone (660 mg), m.p. 228°-229° C., λmax (EtOH) 240 nm (ε 16,370) 300.5 nm (ε 13,090).

후처리

  1. temperatureAfter 1.5 h the mixture was heated to 55° C
  2. temperatureAfter a further 1.5 h the mixture was cooled
  3. customthe resulting precipitate collected
  4. washwashed with cold ethanol
  5. customRecrystallisation twice from ethyl acetate

출처 및 근거

ORD 기록
ord-ab83a1a35df74ae5b92aa9bbb23a3478
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04650800

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