Water → 31309-58-7

HRID 1906201노트

반응식

HRID 1906201 반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[CH3:9][NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH3:9][N:10]([CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7515N-MethylanilineHCID 11430Potassium CarbonateHCID 23393Picolyl chloride

생성물 1

HCID 1421163431309-58-7수율 50.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
120 °C

실험 절차

A mixture of 2-chloromethylpyridine (50 g), N-methylaniline (42 g), and potassium carbonate (120 g) in N,N-dimethylformamide (200 ml) was stirred for 4 hours at 120° C. The reaction mixture was cooled to room temperature, added to water (1 l), and extracted with ether. The ether extract was washed with water and then treated with activated carbon. After drying over magnesium sulfate, the ether extract was filtered and concentrated. The residue was crystallized from isopropyl alcohol to give N-methyl-N-(2-pyridylmethyl)aniline (39 g).

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. extractionextracted with ether
  3. extractionThe ether extract
  4. washwas washed with water
  5. additiontreated with activated carbon
  6. dry with materialAfter drying over magnesium sulfate
  7. extractionthe ether extract
  8. filtrationwas filtered
  9. concentrationconcentrated
  10. customThe residue was crystallized from isopropyl alcohol

출처 및 근거

ORD 기록
ord-bbfa271d7f044856993083f5cf71c13e
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04650804

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