Ammonia → HCID 13885367, 화합물

HRID 1906346노트

반응식

HRID 1906346 반응식
[N:1]1([S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[S:14](F)(=[O:16])=[O:15])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1.[NH3:18]>C1COCC1>[N:1]1([S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[S:14]([NH2:18])(=[O:16])=[O:15])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 222Ammonia2회HCID 13885366HCID 13885366, 화합물

생성물 1

HCID 13885367HCID 13885367, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In a 1-l flask was placed 9.8 g. of 2-(azetidin-1-ylsulfonyl)benzenesulfonyl fluoride and 500 ml of THF. Then 9 ml of ammonia was added and the mixture was refluxed for two days. Four 25 ml portions of liquid ammonia were then added to the refluxing solution over a 48 hour period. The reaction mixture was concentrated and the residue chromatographed on silica gel (dichloroethane). The desired product was collected to give 4.9 g of a solid m.p. 121°-123° C.

후처리

  1. customIn a 1-l flask was placed
  2. temperaturethe mixture was refluxed for two days
  3. concentrationThe reaction mixture was concentrated
  4. customthe residue chromatographed on silica gel (dichloroethane)
  5. customThe desired product was collected

출처 및 근거

ORD 기록
ord-b4661df4c4b34930b3f74a1af7f87b47
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04652304

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