Triethylamine → HCID 13799782, 화합물

HRID 1906394노트

반응식

HRID 1906394 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][S:5](Cl)(=[O:7])=[O:6].[NH2:9][C:10]([CH3:14])([CH3:13])[C:11]#[N:12].C(N(CC)CC)C>C(Cl)Cl>[CH3:13][C:10]([NH:9][S:5]([CH2:4][CH2:3][CH2:2][Cl:1])(=[O:7])=[O:6])([CH3:14])[C:11]#[N:12]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 154103-Chloropropanesulphonyl chlorideHCID 880222-Amino-2-methylpropionitrile

생성물 1

HCID 13799782HCID 13799782, 화합물수율 88.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirred mixture of 9.90 g (0.05 mole) 3-chloropropane sulfonyl chloride and 4.71 g (0.056 mole) 2-amino-2-methyl-propionitrile in 100 ml methylene chloride at 0° C., 5.66 g (0.056 mole) triethylamine as a 10% solution in methylene chloride was added very slowly. The reaction mixture was allowed to stir overnight in the gradually melting ice bath. The reaction mixture was washed three times with 50 ml water. The organic layer was dried over calcium sulfate and evaporated to give 9.90 g of the above-identified product as a brown oil.

후처리

  1. washThe reaction mixture was washed three times with 50 ml water
  2. dry with materialThe organic layer was dried over calcium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-713009c3297d4ce6b18085c91542da66
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04652556

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